A mouse model for CNS disorders.
Inventors: Gabriel Corfas
Invention Types: Research Tool, Therapeutics
Research Areas: Endocrinology, Neurology/Neuroscience
Keywords: Disease ModelFor More Information Contact: Ives, Catherine L.
Transgenic mice expressing a dominant negative erbB receptor in astrocytes (CNS) display an impaired astrocytic neuregulin-erbB receptor signaling resulting in a delayed sexual development and diminished reproductive capacity. These animals represent a valuable preclinical model for screening and validation of drugs for CNS disorders, such as endocrinological dysfunctions and schizophrenia
Five hundred million people worldwide suffer from CNS diseases, people affected by mental, neurological or behavioral problems, including schizophrenia. We have generated novel transgenic mouse models exhibiting neurological and endocrinological disorders. These mice present a unique opportunity for screening, testing and validation of drugs designed to prevent, treat and cure CNS pathologies as well as puberty and reproductive defects.
Key Publications: Prevot V, et al. Normal female sexual development requires neuregulin-erbB receptor signaling in hypothalamic astrocytes. J Neurosci. 2003 Jan 1;23(1):230-9.
Sandau US, et al. SynCAM1, a synaptic adhesion molecule, is expressed in astrocytes and contributes to erbB3 receptor-mediated control of female sexual development. Endocrinology. 2011 Jun;152(6):2364-76.
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