Ferroportin Nucleic Acids, Proteins and Antibodies
Inventors: Leonard Zon, Adriana Donovan
Invention Types: Diagnostic/Prognostic, Therapeutics
Research Areas: Cardiovascular/Cardiology, Immunology, Metabolic Disease, Oncology/Hematology
Keywords: Antibody, Composition of Matter, Gene, ProteinFor More Information Contact: Wong, Adrienne
Altered iron metabolism is linked to the pathology of many diseases, such as hemachromatosis and anemias associated with chronic disease. The zebrafish weissherbst gene was identified by positional cloning from mutant zebrafish with congenital anemia. The gene was shown to express a novel protein, ferroportin, that localizes to the membrane of the yolksac and functions as an iron transporter. Mammalian homologues were isolated, and ferroportin expression was demonstrated in enterocytes of the duodenum, and in the spleen, liver, placenta, brain and macrophages. Ferroportin as been demonstrated to be the major transporter of iron egress out of cells, and is crucial for release of iron into the circulation from absorption in the digestive tract and for release of iron scavenged from hemogloblin during red blood cell turnover. Ferroportin is the target of hepcidin, the master regulator of iron hemostasis, so it is a key target for systemic regulation of iron availability.
Issued US patents 7,166,448 and 7,521,055 and pending continuations claim mammalian ferroportin nucleic acids, proteins and antibodies, which have application in diagnostics and therapeutics for a wide range of disorders of iron homeostasis.
Disorders of iron metabolism include hemochromatosis and anemias, including anemia of chronic disease associated with various conditions including malignancies and response to chemotherapy, autoimmune dsiorders, leukemias, inflammation and infections. Ferroportin nucleic acid are crucial to the detection of genetic and gene espression alterations in iron metabolism disorders. Anti-ferroportin antibodies offer promise for therapeutic intervention in iron homeostasis.
Key Publications: Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000 Feb 17;403(6771)
Fraenkel PG, Traver D, Donovan A, et al. Ferroportin1 is required for normal iron cycling in zebrafish. J Clin Invest. 2005 Jun; 115(6)