miR-19a/b stimulates cardiac regeneration
Inventors: Dazhi Wang, Jinghai Chen
Invention Types: Therapeutics
Research Areas: Cardiovascular/Cardiology
Keywords: Cell Therapy, Heart DiseaseFor More Information Contact: Herrera Gutierrez, Aida
Cardiomyocytes in adult mammalian hearts are terminally differentiated and lack the capacity to regenerate. Death of cardiomyocytes are primary causes of heart failure and mortality. An ability to regenerate heart tissues could bring a valuable new treatment for patients.
In 2013, Drs. Da Zhi Wang and Jinghai Chen identified the miR-17-92 cluster of microRNAs as critical regulators of cardiomyocyte proliferation. The researchers found that overexpression of miR-17-92 induces cardiomyocyte proliferation in embryonic, postnatal, and adult hearts. They identified that miR-19a/b, in particular, is required for and sufficient to induce cardiomyocyte proliferation in vitro.
Recently, Dr. Wang has tested miR-19a/b as a treatment for heart attack. His team tested both intra-cardiac injection of miR-19a/b mimetics and AAV-vector delivered miR-19a/b in a mouse model of myocardial infarct injury. They found that both approaches reduced cardiac damage and protected cardiac function by stimulating cardiomyocyte proliferation.
These studies suggest that miR-19a/b has the potential to be therapeutic agents for cardiac repair and heart regeneration.
Death of mature cardiomyocytes in pathological cardiac conditions and the lack of regeneration capacity of adult hearts are primary causes of heart failure and mortality. miR-17-92 is required for cardiomyocyte proliferation in the heart.
miR-19a/b induces cardiomyocyte proliferation in myocardial infarction-induced injury.
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Key Publications: Gao F, et al. Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. Nat Commun. 2019 April 17;10(1):1802
Chen J, et al. mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res. 2013 Jun 7;112(12):1557-66.
Related Publications: https://vector.childrenshospital.org/2019/04/micrornas-heart-attack/