Topical anti-microbial agents for the prevention of STDs and other viral infections
Inventors: Judy Lieberman, Manjunath Narasimhaswamy
Invention Types: Therapeutics
Research Areas: Infectious Disease
Keywords: siRNAFor More Information Contact: Ives, Catherine L.
The novel agents of this invention comprise short interference RNAs (siRNAs) that either down-regulate genes necessary for viral reproduction or down-regulate the cellular receptors necessary for infection thereby preventing entry of the virus or microbe into target cells such as macrophages and T cells. The preferred method of delivery of the siRNAs into human subjects comprises applying a topical composition consisting of naked or chemically modified double-stranded siRNAs conjugated to a pharmaceutically acceptable carrier. Sequences and vectors are claimed for siRNAs that inhibit the expression of viral genes. Recent studies have shown that siRNA delivery and gene silencing can be achieved in the mouse vagina with lasting results.
The present invention provides compositions and methods for prevention of sexually transmitted diseases including but not limited to HIV, hepatitis B, herpes and papilloma virus infection by modulating the expression of the corresponding genes through RNA interference or post-transcriptional gene silencing.
Delivery mediums may include eye drops, lip balm, lip stick, ointment, cream, paste, emulsion, foam, jelly, gels or a spray.
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US Patent Issued #7,696,179