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CMCC 1468

Novel Two Piece Replacement Heart Valve Delivered via Transcatheter

Inventors: James Lock, Doff McElhinney

Invention Types: Medical Device

Research Areas: Cardiovascular/Cardiology

Keywords: Medical Device

For More Information Contact:  Herrera Gutierrez, Aida


Invention Description:

Drs. Lock and Nugent have modeled a two piece replacement heart valve apparatus that is administered via a catheter. The heart valve apparatus includes a stent and a valve frame having a substantially cylindrical body defining a lumen. The valve frame includes a plurality of curved wire pairs attached to a cylindrical body. Each curved wire pair includes an inner curved wire and an outer curved wire. Also, the wire frame has a plurality of leaflets. Each leaflet is attached to a respective inner curved wire and extends over an outer curved wire to position the body of the leaflet within the lumen of the valve frame (CMCC 801).|

In addition to the apparatus above, Drs. Drs. Lock and McElhinney have added a docking station for positioning within the lumen. The docking station includes a diaphragm adapted to have an open and a closed position, which provides a temporary control mechanism for preventing free regurgitation during the time period between the deployment of the docking station and the deployment of the valve frame, and a sealing mechanism for preventing paravalvar leakage (CMCC1468)


Minimally invasive systems and methods for heart valve for treatment in pediatric patients with:|

• Heart valve dysfunction|

• Congenital heart disease|

• Pulmonary regurgitation|

• Diseased or abnormal natural heart valves|

Competitive Advantages:

• In 2006, the American College of Cardiology reports that approximately 12,000 isolated aortic valve replacements were made each year from 1999 to 2004|

• Less invasive than surgery and will alleviate problems from surgical placement, including:|

o postoperative complications that include heart valve dysfunction.|

o subsequent leaking (i.e., regurgitation) of blood through the pulmonary valve|

o Scarring|

o surgical valve replacement in pediatric patients do not grow with the patient and thus require more frequent replacement.|

• No need for a heart-lung machine|

• Cheaper than surgery|

• Quick recovery time|

• Bioprosthetic heart valves devices that combine a mechanical assembly with biological material (e.g., human, porcine, bovine, or biopolymer leaflets) include an additional support structure, such as a stent, to support the leaflets of the valve. |

o The stent also absorbs the stresses, which would otherwise be borne by the leaflets, from the hemodynamic pressure exerted during normal heart operation.|

Business Opportunity:

Exclusive license to patents and know-how

Key Publications: US Patent # 7,470,285|

Published PCT WO/2007/130537

IPStatus: Patented