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131 results found

INVENTION NAME

PI NAME

Therapy for non-small cell lung cancer using dual EZH2 inhibition and chemotherapy

Keywords: Biomarker, Cell Line, Drug Discovery, Gene expression

Kim, Carla

Gene expression signature that identifies DNA repair and predicts tumor sensitivity to drugs

Keywords: Drug Screening

Szallasi, Zoltan

Treatment, Prevention, and Mouse Models of Neutrophil-Derived NET Toxicity in Thrombosis, Cancer and Diabetes

Keywords: Animal Model (mouse)

Wagner, Denisa D.

Ferroportin Nucleic Acids, Proteins and Antibodies

Keywords: Antibody, Composition of Matter, Gene, Protein

Zon, Leonard I.

Collagen XXIII: A novel biomarker for non-small cell lung cancer and prostate cancer

Keywords: Biomarker

Zetter, Bruce

Z-score Dataset Package

Keywords: Pediatric, Database

Colan, Steven D.

Novel Fluorine-18 Labeled Rhodamine Derivatives For Myocardial Perfusion Imaging With Positron Emission Tomography

Keywords: Composition of Matter, Reagent, Small Molecule/Drug

Packard, Alan

SonneWheel (TM) Pediatric BMI Assessment Tool

Keywords:

Sonneville, Kendrin R.

Methods to predict, prevent and revert resistance to taxoid compounds

Keywords: Biomarker, Method of Use

Zetter, Bruce

Urine Biomarkers for Bladder Cancer

Keywords: Biomarker

Zetter, Bruce

Genetic Test Predictive of Severity of Cystic Fibrosis Pulmonary Disease

Keywords: SNPs

Levy, Hara

Method to quantify high affinity lgE receptor alpha chain to monitor allergic diseases

Keywords: Assay, Biomarker, Large Molecule, Receptor/Ligand

Fiebiger, Edda

Diagnostic Test for Developmental Delay or Autism

Keywords: Biomarker, Genomics, Pediatric

Wu, Bai-Lin

Treatment and Diagnostic for Melanomas

Keywords: Animal Model (zebra fish), Biomarker

Zon, Leonard I.

Device for transcutaneous detection of vagus nerve stimulation

Keywords:

Rotenberg, Alexander

Early Autism Diagnosis and Risk Assessment Using Complex Systems Analysis of EEG Signals

Keywords: Autism, Pediatric, Software

Bosl, William J.

Novel HIV Vaccine Immunogens for Eliciting Neutralizing Antibodies

Keywords: Protein, Vaccine

Chen, Bing

Biomarker panel for the diagnosis of cardiac allograft vasculopathy

Keywords: Organ Transplant

Briscoe, David

Glycomics and Proteomics Simultaneously (GAPS): A rapid and novel sample preparation pipeline for complex glycoproteins

Keywords: Assay, Proteomics, Reagent

Lee, Richard

miRNA-135a to detect and reverse taxane resistance in tumor cells

Keywords: Biomarker, Cell Line, Method of Use

Zetter, Bruce

Novel malignancy associated response signatures associated with refractory tumors

Keywords: Drug Screening, Stem/Progenitor Cell

Lieberman, Judy

Improved characterization of white matter fascicles using cube and sphere diffusion MRI

Keywords: Biomarker, Imaging

Warfield, Simon

Improved white matter imaging using a novel computational model

Keywords: CNS, Instrumentation, Imaging

Warfield, Simon

Improved characterization of lesions using a novel DW-MRI analysis method

Keywords: Software, Imaging

Warfield, Simon

Curated gene list for diagnosis of sudden unexpected death in pediatrics

Keywords: Biomarker, Gene expression, Neonatology/Pediatric, Pediatric

Goldstein, Richard

GlycoPipe: Simple and Sensitive Glycoproteomics

Keywords: Drug Discovery, Instrumentation, Protein, Proteomics

Froehlich, John

Platform to assess extracellular vesicles transport across the blood brain barrier

Keywords: Assay, CNS, Disease Model, Drug Delivery, Drug Discovery, Drug Screening, Method of Use, Tissue Engineering, Platform

Moses, Marsha

AudioHub: Mobile software for better management and analysis of hearing assessment data in the clinic

Keywords: Pediatric

Shane, Howard

Headache tools to stay in school

Keywords: Pain

Lazdowsky, Lori

Novel Algorithm for High Speed Medical Image Processing

Keywords: Instrumentation, Software

Warfield, Simon

Improved mass spectrometry-based multiplexing strategies for quantitative proteomics

Keywords: Proteomics, Software

Steen, Hanno

GRAEZing: A classifier to increase glycoproteomic coverage

Keywords: Software

Lee, Richard

Detection of epilepsy with analysis of electromagnetic signals (EEG)

Keywords: Software

Bosl, William J.

GlazeR: A glycosylation analysis software for mass spectrometry data

Keywords: Drug Discovery

Lee, Richard

Contact Lens Drug Delivery Device

Keywords: Instrumentation, Method of Use

Kohane, Daniel S.

Microfluidic devices for magnetic separation in continuous flow

Keywords: Patient Care

Ingber, Donald

Novel Two Piece Replacement Heart Valve Delivered via Transcatheter

Keywords: Medical Device

Lock, James

Enabling Devices for Beating Heart Intracardiac Surgery - 1 (Valve Repair Clip)

Keywords:

del Nido, Pedro J.

Hydration Monitor

Keywords: Medical Device, Patient Care

Bezzerides, Vassilios J.

Nanowired three-dimensional cardiac patches

Keywords: Surgery, Tissue Engineering

Dvir, Tal

Surface-Modified Circuits for Blood Modification

Keywords: Medical Device, Patient Care, Polymer

Kohane, Daniel S.

Three-dimensional synthetic biomaterials as structural and bioactive scaffolds

Keywords: Tissue Engineering

Kohane, Daniel S.

A cell-free, silk-based scaffold for regenerating bladder tissue

Keywords: Instrumentation, Method of Use, Surgery, Tissue Engineering

Mauney, Joshua

Devices and methods of papillary muscle approximation for tricuspid valve repair and ventricular remodeling

Keywords: Surgery

del Nido, Pedro J.

Robotic Implant to Apply Tissue Traction Forces in the Treatment of Esophageal Atresia

Keywords: Surgery

Dupont, Pierre

Extremely Short Magnet Needle

Keywords:

Liu, Kaifeng

Silk fibroin bilayer grafts for reconstruction of esophageal defects

Keywords: Tissue Engineering

Mauney, Joshua

Novel AIDS Vaccine

Keywords: Vaccine

Aldovini, Anna

DVD: ''Raising your Celiac Child: Guidelines for a Gluten-free Life''

Keywords: Patient Care

Leichtner, Alan

Video: Safe Care in the Operating Room

Keywords:

Norton, Elizabeth

Peptide-binding Nanobody for Biochemical Applications

Keywords: Antibody, Method of Use, Protein, Reagent, Molecular biology, Imaging

Ploegh, Hidde

Novel age-specific vaccine testing platform

Keywords: Assay, Vaccine, Platform

Levy, Ofer

Engineered Antibody Class Switch Recombination

Keywords: Antibody

Chiarle, Roberto

CELL-TYPE SPECIFIC SYSTEMIC DELIVERY OF siRNA

Keywords:

Lieberman, Judy

A method for detection of recurrent and non-specific double-stranded DNA break locations in the genome

Keywords: Assay, Molecular biology

Alt, Frederick W.

Conformation-stabilized TRAP antigens for malaria vaccines

Keywords: Vaccine

Springer, Timothy

Neurokinin-1 Receptor Knock-Out Mouse

Keywords: Animal Model (mouse), Drug Screening

Gerard, Craig

C3aR Knock-Out Mice

Keywords: Animal Model (mouse), Drug Discovery, Drug Screening

Gerard, Craig

A mouse model for CNS disorders.

Keywords: Disease Model

Corfas, Gabriel

Bacterial Ion Channel, a Platform for Screening Ion Channel Agonists and Antagonists

Keywords: Drug Screening, Ion Channels

Clapham, David

Mouse Model for Drug Development and Research in: (1) Myelination Abnormalities such as ALS (Amyotrophic Lateral Sclerosis), Schizophrenia, Bipolar Disorder; and (2) Drug Addiction

Keywords: Animal Model (mouse), Drug Discovery, Drug Screening, Small Molecule/Drug

Corfas, Gabriel

Mouse Model for Drug Development and Research in Peripheral Sensory Neuropathies

Keywords: Animal Model (mouse), Disease Model, Drug Discovery, Drug Screening

Corfas, Gabriel

Monoclonal Antibodies to Native Murine CCR9

Keywords: Antibody, Reagent

Campbell, James

High Performance GAP-43 Antibody to Detect Axonal Regeneration for Drug Development and Research

Keywords: Antibody, Drug Discovery

Benowitz, Larry

Antibody against the N-terminus of GLT-1/EAAT2

Keywords: Antibody

Rosenberg, Paul

Defining physiological functions of syndecan-1 in health and disease using the syndecan-1 null mice

Keywords: Animal Model (mouse)

Park, Pyong W.

Discovery of GSK3ß inhibitors to treat neuromuscular diseases through novel zebrafish screening platform

Keywords: Animal Model (zebra fish), Drug Screening, Small Molecule/Drug

Zon, Leonard I.

Efficient and specific gene knockdown by siRNAs produced in bacteria

Keywords: Drug Delivery, siRNA

Lieberman, Judy

Chemical inducer of dimerization cleavable by light

Keywords: Cell Signaling

Schwarz, PhD, Thomas

Device and methods for analyzing rodent behavior using light technology

Keywords: Instrumentation, Method of Use

Woolf, Clifford

Conversion of somatic cells into nociceptors

Keywords: Assay

Woolf, Clifford

Mouse Model for Generation of Antibodies and Vaccine Antigens

Keywords: Antibody, Vaccine, Mouse Model, Platform

Alt, Frederick W.

MStern blotting: An improved method of sample preparation for mass spectrometry-based proteomics

Keywords: Assay, Proteomics

Steen, Hanno

Novel Antibiotic from a Costa Rican Fungus

Keywords: Assay, Drug Screening, Neonatology/Pediatric

Watnick, Paula I.

Novel and highly efficient production of red blood cells

Keywords: Stem/Progenitor Cell

Sankaran, Vijay

Method to derive microglia from hematopoietic progenitor and stem cells

Keywords: Assay, Cell Line, Cell Therapy, CNS, Drug Screening

Rossi, Derrick

Novel pathway and treatments for pathological retinal angiogenesis

Keywords: Anti-angiogenesis, Small Molecule/Drug, Cell Signaling, Gene Therapy

Smith, Lois

miRNAs as therapeutic modulators to treat blood cancers

Keywords:

Lieberman, Judy

CD45 Phosphatase Inhibition as a Treatment for Heart Disease and Fibrosis

Keywords: Heart Disease

Bischoff, Joyce

Improving DNA repair efficiency for CRISPR/Cas9-mediated genome editing

Keywords: Gene, Gene Therapy

Rossi, Derrick

Novel use of senicapoc to treat or prevent malaria

Keywords: New Indication/Use, Small Molecule/Drug, Target

Tubman, Venee

Ffar1 inhibitors that target dysfunctional energy metabolism in the eye to treat retinopathies

Keywords:

Smith, Lois

Innovative Uses of Biofilms for Protein Delivery, Vaccine Development, and Infectious Disease Treatment

Keywords: Drug Delivery

Watnick, Paula I.

CYP2C8: a target for treating and preventing vascular diseases of the retina

Keywords: Drug Discovery, Small Molecule/Drug

Smith, Lois

Administration of inosine to stimulate innervation and recovery of motor function

Keywords: Spinal Cord Injury, Stroke

Benowitz, Larry

TIMP2 Loop 6 peptide: an endogenous angiogenesis inhibitor

Keywords: Anti-angiogenesis, Composition of Matter, Peptide

Moses, Marsha

Caplostatin, a novel anti-angiogenic polymeric drug

Keywords: Anti-angiogenesis, Composition of Matter, Small Molecule/Drug

Satchi-Fainaro, Ronit

Recombinant VP4 Polypeptides as Antigens for a Rotavirus Vaccine

Keywords: Vaccine

Harrison, Stephen

Inhibition of dengue infection by binding of drugs to a novel site on dengue E protein.

Keywords: Drug Discovery, Drug Screening, Drug Design

Harrison, Stephen

Endostatin Peptides with Anti-Tumor Properties

Keywords: Anti-angiogenesis, Composition of Matter, Peptide, Gene Therapy

Javaherian, Kashi

Stimulating Axon Regeneration by Blocking EGF Receptor Activity

Keywords: Assay, Drug Discovery, Small Molecule/Drug, Spinal Cord Injury

He, Zhigang

Ion channel inhibition to minimize stroke's secondary damage

Keywords: Drug Screening

Clapham, David

Intravenous Oxygen

Keywords: Patient Care, Polymer

Kheir, John N.

Novel Treatment for Polycystic Kidney Disease (PKD)

Keywords: Animal Model (mouse), New Indication/Use, Small Molecule/Drug

Kreidberg, Jordan A.

Lodamin for the Treatment of Cancer

Keywords: Anti-angiogenesis, Composition of Matter, Small Molecule/Drug

Folkman, M. J.

Combination treatment for melanoma

Keywords: Animal Model (zebra fish)

Zon, Leonard I.

Treatment of Airway Hyperreactivity

Keywords: Disease Model, Patient Care

Umetsu, Dale

Fetal Tissue Engineered Patches to Repair Congenital Anomalies

Keywords: Surgery, Tissue Engineering

Fauza, Dario

Oral delivery of therapeutic large molecules

Keywords: Drug Delivery

Lencer, Wayne

Novel peptides to promote wound healing and neuroprotection

Keywords: Composition of Matter, Peptide

D'Amato, Robert

Novel Pneumococcal Vaccine with Adjuvant Properties

Keywords: Composition of Matter, Method of Use, Vaccine

Malley, Richard

Novel Treatment for Angiogenesis-dependent Diseases

Keywords: Anti-angiogenesis, Ion Channels

Ingber, Donald

Modulators of Nitric Oxide Signaling for the Stimulation Hematopoietic Stem Cells

Keywords: Stem/Progenitor Cell

Zon, Leonard I.

Novel Treatment for Ocular Neovascularizing Diseases

Keywords: Animal Model (mouse), Anti-angiogenesis

Ingber, Donald

Novel Approaches for HIV Vaccines that Elicit Neutralizing Antibodies: gp41 Locked in Fusion-intermediate Conformation

Keywords: Vaccine

Harrison, Stephen

Rapamycin and its analogs as novel treatments for hemangiomas

Keywords: Disease Model, Drug Screening, New Indication/Use, Dermatologic

Bischoff, Joyce

Wnt antagonists for treatment and prevention of osteoporosis

Keywords: Large Molecule

He, Xi

Inhibitors of GABA transaminase and NKCC1 as an anticonvulsant

Keywords: Pediatric

Jensen, Frances E.

Lodamin for Treating Eye Diseases

Keywords: Anti-angiogenesis

D'Amato, Robert

Novel Asthma Vaccine Candidate

Keywords: Chronic Disease, Pediatric, Vaccine

Umetsu, Dale

Delivery of Therapeutic Compounds Across the Blood Brain Barrier

Keywords: CNS, Drug Delivery, Transfection

Narasimhaswamy, Manjunath

Chimeric peptides for the treatment of cancer

Keywords: Drug Discovery, Large Molecule

Williams, David A.

Treatment of thrombosis and prevention of toxicity caused by neutrophil extracellular traps (NETs)

Keywords: Method of Use

Wagner, Denisa D.

Peptide-based inhibitor for treating chronic viral and autoimmune inflammatory diseases

Keywords: Small Molecule/Drug

Kagan, Jonathan

Influenza Virus Vaccine Strategy

Keywords: HIV, Vaccine

Harrison, Stephen

miR-19a/b stimulates cardiac regeneration

Keywords: Cell Therapy, Heart Disease

Wang, Dazhi

Chelation of zinc promotes nerve regeneration within the central nervous system

Keywords: CNS, Neuropathy, New Indication/Use, Polymer, Small Molecule/Drug, Spinal Cord Injury, Stroke, Target

Benowitz, Larry

Topical anti-microbial agents for the prevention of STDs and other viral infections

Keywords: siRNA

Lieberman, Judy

Extracellular Matrix Modulators as Therapeutics for Prevention of Vascular Leakage

Keywords: Heart Disease, Organ Transplant

Ingber, Don

Innovative Uses of Biofilms for Protein Delivery, Vaccine Development, and Infectious Disease Treatment

Keywords: Drug Delivery, Protein, Vaccine, Platform

Watnick, Paula I.

Therapeutic for viral infection-triggered asthma with c-Kit inhibitor

Keywords:

Umetsu, Dale

Novel adjuvant supplement to boost vaccine efficacy

Keywords: Assay

Kagan, Jonathan

DEPTOR as a target for the treatment of chronic inflammation and angiogenesis-dependent diseases

Keywords: Drug Discovery

Briscoe, David

CD154 as a target for the treatment of thrombotic and inflammatory diseases

Keywords: Drug Discovery, Drug Screening

Wagner, Denisa D.

Novel mechanism and compound for the treatment of metastatic cancers

Keywords:

Zetter, Bruce

Reinvigoration of exhausted T-cell by targeted activation of lipid scramblase, TMEM16F

Keywords:

Winau, Florian

Dietary Fatty Acid Approach to Improve Fertility in Aging

Keywords: Animal Model (mouse), Method of Use, Stem/Progenitor Cell, Mouse Model

Puder, Mark

Novel therapeutic target to treat nerve damage by promoting neuronal survival and regeneration

Keywords: CNS, Neuropathy, Spinal Cord Injury, Target

He, PhD, BM, Zhigang

Dual-targeting liposome-based drug delivery system

Keywords: Animal Model (mouse), Drug Delivery, Gene expression, Receptor/Ligand, Cell Signaling, Drug Design, Platform

Moses, Marsha

Nanoparticles targeting gene editing systems to cancer cells

Keywords: Animal Model (mouse), Composition of Matter, Drug Delivery, Gene expression, Receptor/Ligand, Drug Design, Gene Therapy, Platform

Moses, Marsha

Novel Age-Specific Adjuvants

Keywords: Drug Discovery, Neonatology/Pediatric, Peptide, Small Molecule/Drug, Vaccine

Levy, Ofer

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