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CMCC 917

A mouse model for CNS disorders.

Inventors: Gabriel Corfas

Invention Types: Research Tool, Therapeutics

Research Areas: Endocrinology, Neurology/Neuroscience

Keywords: Disease Model

For More Information Contact:  Caron, Connie

 

Invention Description:

Transgenic mice expressing a dominant negative erbB receptor in astrocytes (CNS) display an impaired astrocytic neuregulin-erbB receptor signaling resulting in a delayed sexual development and diminished reproductive capacity. These animals represent a valuable preclinical model for screening and validation of drugs for CNS disorders, such as endocrinological dysfunctions and schizophrenia

Applications:

Disease Model

Drug Discovery

Drug Screening

Research Tool

Competitive Advantages:

Five hundred million people worldwide suffer from CNS diseases, people affected by mental, neurological or behavioral problems, including schizophrenia. We have generated novel transgenic mouse models exhibiting neurological and endocrinological disorders. These mice present a unique opportunity for screening, testing and validation of drugs designed to prevent, treat and cure CNS pathologies as well as puberty and reproductive defects.

Business Opportunity:

Non-Exclusive License

IPStatus: No Protection