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CMCC 600

Administration of inosine to stimulate innervation and recovery of motor function

Inventors: Larry Benowitz, David Goldberg

Invention Types: Therapeutics

Research Areas: Neurology/Neuroscience, Surgery/Wound Healing

Keywords: Spinal Cord Injury, Stroke

Related Cases: 1183, 1709

For More Information Contact:  Caron, Connie

 

Invention Description:

There are an estimated 10,000 to 12,000 spinal cord injuries every year in the United States. A quarter of a million Americans are currently living with spinal cord injuries. The cost of managing the care of spinal cord injury patients approaches $4 billion each year. (Facts and Figures at a Glance, May 2001. National Spinal Cord Injury Statistical Center).

According to the America Heart Association, among adults age 20 and older, the prevalence of stroke in 2005 was 6.5 million and each year about 795,000 people experience a new or recurrent stroke. About 600,000 of these are first attacks, and 185,000 are recurrent attacks.

The inventors have found that inosine, a naturally occurring substance, could improve outcomes following injury by stimulating reinnervation of damaged brain regions.

Inosine could be used alone or in combination with other trophic factors, such as mannose or oncomodulin, or in combination with inhibitors of pathways that block axon growth.

Additional cases in this portfolio:
CMCC 924: Inventors Larry Benowitz and Nina Irwin
CMCC 1154: Inventors Larry Benowitz and Dietmar Fischer
CMCC 1709: Inventor Nina Irwin

Applications:

Use of inosine and other molecules that would modulates inosine's target (Mst3b) in combination with inhibitors of pathways that block axon growth such as Nogo Receptor (NgR) inhibitor to treat:
• Spinal Cord Injury
• Stroke
• Possibly neurodegenerative diseases or conditions

Competitive Advantages:

• There is no treatment for spinal cord injuries.
• Inosine is known to be safe: it is now in clinical trials for other indications such as Parkinson's disease and may have applications in other types of neurological damage.
• Inosine is known to cross the blood-brain barrier suggesting that delivery could be straight forward.

Business Opportunity:

Available for exclusive or non-exclusive license
Opportunity for sponsored research and co-development
• Analogs and formulations of inosine
• Preclinical studies on therapeutic window and optimizing conditions for delivery
• Clinical trials for enhancing brain plasticity after stroke
• Clinical trials for improved outcomes after stroke, SCI and other neurological conditions

Key Publications:
Chen P, et al. Inosine induces axonal rewiring and improves behavioral outcome after stroke. Proc Natl Acad Sci USA. 2002 Jun 25;99(13):9031-6.

Irwin N, et al. Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth. Proc Natl Acad Sci USA. 2006 Nov 28;103(48):18320-5.

Zai L, et al. Inosine alters gene expression and axonal projections in neurons contralateral to a cortical infarct and improves skilled use of the impaired limb. J Neurosci. 2009 Jun 24;29(25):8187-97.

Benowitz LI, Carmichael ST. Promoting axonal rewiring to improve outcome after stroke. Neurobiol Dis. 2010 Feb;37(2):259-66.

Zai L, et al. Inosine augments the effects of a Nogo receptor blocker and of environmental enrichment to restore skilled forelimb use after stroke. J Neurosci. 2011 Apr 20;31(16):5977-88.

Kim D, et al. Inosine enhances axon sprouting and motor recovery after spinal cord injury. PLoS One. 2013 Dec 2;8(12):e81948.

Dachir S, et al. Inosine improves functional recovery after experimental traumatic brain injury. Brain Res. 2014 Mar 25;1555:78-88.

Moore TL, et al. Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey. Restor Neurol Neurosci. 2016 Sep 21;34(5):827-48.

Chung YG, et al. Inosine improves neurogenic detrusor overactivity following spinal cord injury. PLoS One. 2015 Nov 3;10(11):e0141492.

IPStatus: Patented