Antiangiogenic Agents for Treatment of Endometriosis
Inventors: Nancy Klauber, Robert D'Amato
Invention Types: Therapeutics
Research Areas: Endocrinology, Reproduction/Ob-Gyn
Keywords: Anti-angiogenesis, New Indication/UseFor More Information Contact: Dietz, Ryan
Angiogenesis, the sprouting of new blood vessels, normally occurs in the female reproductive organs. Drs. D'Amato and Klauber have shown that anti-angiogenic agents can control fertility in mice. Moreover, anti-angiogenic therapies inhibited lesions in a mouse model of surgically induced endometriosis.
This data suggests that anti-angiogenic agents could be used to prevent pregnancy and to treat endometriosis. Endometriosis is a debilitating condition that affects approximately 15% of females of reproductivage, with over 5.5 million women afflicted in the United States alone. It is estimated that 71-87% of women with chronic pelvic pain suffer from endometriosis and that 25-40% of infertility cases are the result of endometriosis. This form of therapy may also be used to treat other conditions of the female reproductive system such as adenmyosis, dysfunctional uterine bleeding, choriocarcinoma and ectopic pregnancy.
There is currently no cure for endometriosis, with extreme cases requiring a hysterectomy. Standard treatments, such as pain medications, hormones and surgeries to remove existing lesions, only alleviate symptoms temporarily and are associated with significant side effects, including osteoporosis. Dr. D'Amato and colleagues have found that the vasculature is a novel target for treatment of endometriosis. The invention disclosed here is a novel treatment for endometriosis and other disorders which affect the female reproductive tract.
Key Publications: Nature Medicine, 1997 Apr;3(4):443-6.