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CMCC 2682

GlazeR: A glycosylation analysis software for mass spectrometry data

Inventors: Richard Lee, John Froehlich, Peter Warren

Invention Types: Information Technology/Software, Therapeutics, Research Tool

Research Areas:

Keywords: Drug Discovery

For More Information Contact:  Khunkhun, Rajinder

 

Invention Description:

Glycosylation is one of the most common protein modifications: it is estimated to be present in >50% of all human proteins. Even minor changes in the composition or pattern of glycosylation can have tremendous impacts on the function, structure, stability and biological activity of proteins. While mass spectrometry (MS) can provide valuable information for the study of protein glycosylation, the analysis and interpretation of MS data must often be performed manually by experienced specialists.


Dr. Lee and colleagues have developed a new software tool, Glazer, that combines de novo sequencing of glycan moieties and proteomic database approaches to assign tandem spectra to intact glycopeptides. Glazer allows for high-throughput analysis of glycosylation with an integrated scoring system and method for control of false discovery rates.

Applications:

• Glazer is a bioinformatics tool that enables large-scale glycoproteomic studies through the analysis of mass spectrometry data

Competitive Advantages:

• Glazer is compatible with all of the common fragmentation data types, including ECD, ETD, CID, and HCD

• Glazer allows site-specific glycosylation analysis to be performed by those with minimal experience in mass spectrometry analysis/interpretation and without specialized, expensive instrumentation

IPStatus: Pat. Pend.