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CMCC 2613

Improved white matter imaging using a novel computational model

Inventors: Simon Warfield, Benoit Scherrer

Invention Types: Diagnostic/Prognostic, Information Technology/Software

Research Areas: Neurology/Neuroscience

Keywords: CNS, Instrumentation, Imaging

For More Information Contact:  Yen, Alan

 

Invention Description:

Diffusion Tensor Imaging (DTI) is an MRI technique that allows for the investigation of brain microstructure by probing natural barriers to diffusion of water in tissues. The technique can reveal tissue architecture in both normal and disease states. DTI has become the standard technique for imaging white matter disorders.


Simon Warfield, PhD, director of the Computational Radiology Laboratory, and his group at Boston Children’s have developed a novel biophysical model that addresses some of the fundamental limitations of DTI. The technique, known as DIstribution of Anisotropic MicrO-structural eNvironments with Difusion-weighted imaging (DIAMOND), utilizes a generalized statistical distribution model to provide higher resolution of tissue microstructures. In addition, DIAMOND uses a novel acquisition scheme that provides a two-fold reduction in imaging time when compared to state of the art techniques.


The DIAMOND technique was used to image the brain of a patient with Tuberous Sclerosis Complex (TSC), a genetic disorder characterized by the presence of benign tumors in the brain called cortical tubers. The results showed that the estimated fascicle orientations successfully matched the known anatomy. DIAMOND may lead to novel biomarkers and investigation of white matter microstructures in normal and diseases.

Applications:

• Diagnostic imaging to track therapeutic outcomes in oncology.

• Diagnostic imaging for early detection and diagnosis of white matter disorders such as stroke, multiple sclerosis, dementia, and cerebral palsy.

Competitive Advantages:

• Provides a higher resolution image of white matter tissue

• Offers a two-fold reduction in imaging time without compromising resolution

Business Opportunity:

Exclusive or non-exclusive license

Key Publications: Freiman M, Perez-Rossello JM, Callahan MJ, Voss SD, Ecklund K, Mulkern RV,
Warfield SK. Reliable estimation of incoherent motion parametric maps from
diffusion-weighted MRI using fusion bootstrap moves. Med Image Anal. 2013
Apr;17(3):325-36. doi: 10.1016/j.media.2012.12.001. Epub 2013 Jan 3. PubMed PMID:
23434293 |

Scherrer B, Warfield SK. Parametric representation of multiple white matter
fascicles from cube and sphere diffusion MRI. PLoS One. 2012;7(11):e48232. doi:
10.1371/journal.pone.0048232. Epub 2012 Nov 26. PubMed PMID: 23189128

IPStatus: Pat. Pend.