Improved white matter imaging using a novel computational model
Inventors: Simon Warfield, Benoit Scherrer
Invention Types: Diagnostic/Prognostic, Information Technology/Software
Research Areas: Neurology/Neuroscience
Keywords: CNS, Instrumentation, ImagingFor More Information Contact: Yen, Alan
Diffusion Tensor Imaging (DTI) is an MRI technique that allows for the investigation of brain microstructure by probing natural barriers to diffusion of water in tissues. The technique can reveal tissue architecture in both normal and disease states. DTI has become the standard technique for imaging white matter disorders.
Simon Warfield, PhD, director of the Computational Radiology Laboratory, and his group at Boston Children’s have developed a novel biophysical model that addresses some of the fundamental limitations of DTI. The technique, known as DIstribution of Anisotropic MicrO-structural eNvironments with Difusion-weighted imaging (DIAMOND), utilizes a generalized statistical distribution model to provide higher resolution of tissue microstructures. In addition, DIAMOND uses a novel acquisition scheme that provides a two-fold reduction in imaging time when compared to state of the art techniques.
The DIAMOND technique was used to image the brain of a patient with Tuberous Sclerosis Complex (TSC), a genetic disorder characterized by the presence of benign tumors in the brain called cortical tubers. The results showed that the estimated fascicle orientations successfully matched the known anatomy. DIAMOND may lead to novel biomarkers and investigation of white matter microstructures in normal and diseases.
• Diagnostic imaging to track therapeutic outcomes in oncology.
• Diagnostic imaging for early detection and diagnosis of white matter disorders such as stroke, multiple sclerosis, dementia, and cerebral palsy.
• Provides a higher resolution image of white matter tissue
• Offers a two-fold reduction in imaging time without compromising resolution
Exclusive or non-exclusive license
Scherrer B, et al., Characterizing brain tissue by assessment of the distribution of anisotropic microstructural environments in diffusion-compartment imaging (DIAMOND). Magn Reson Med. 2016 Sep;76(3):963-77.
Scherrer B, et al. Characterizing the distribution of anisotropic micro-structural environments with diffusion-weighted imaging (DIAMOND). Med Image Comput Comput Assist Interv. 2013;16(Pt 3):518-26.
IPStatus: Pat. Pend.