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CMCC 2569

Biodegradable mesostructured polymer membranes for tissue engineering

Inventors: Daniel Kohane, Bozhi Tian

Invention Types: Medical Device, Therapeutics

Research Areas: Surgery/Wound Healing

Keywords: Tissue Engineering

For More Information Contact:  Khunkhun, Rajinder

 

Invention Description:

Mesostructured constructs are important for a range of potential applications such as tissue engineering, medicine, and optics.


Dr. Dan Kohane and Dr. Bozhi Tian have developed methods to create biodegradable porous membranes that could be used to improve engineered tissues and organs, and for other uses. These membranes may be formed from biocompatible and/or biodegradable materials and may be developed using solvent evaporation induced self-assembly (EISA) techniques. The pores within the membrane have similar size of pores in the extracellular matrix, which will help promote cell growth in engineered tissues.

Applications:

• A method or kit to produce cell promoting and biodegradable membranes for engineered tissues and organs.

• Ultrathin temporary substrate for engineering vascular (or other) tissue constructs.

• Biodegradable filter membrane for vapor and liquid molecules.

• Nanoporous drug delivery patch.

• Permeable coating, membrane or sac for cell/implant encapsulation and immunoisolation.

• Permeable ultrathin substrate for flexible electronics.

• Textile or cloth materials.

• Temperature and solvent responsive materials.

Competitive Advantages:

• Facile synthesis of mesostructured polymers with biomaterial compositions needed, but is yet to be achieved.

• This method will allow for the development of biodegradable, engineered tissues that will promote cell growth.

• The mesostructured materials were nonionic, hydrophilic, and water-permeable, and could be shaped into arbitrary geometries such as conformally-molded tubular sacs and micropatterned meshes.

• This technology has the potential to overcome issues with organ rejections that previous tissue engineered technologies have been unable to overcome.

Business Opportunity:

Exclusive license or sponsored research

IPStatus: Pat. in Prep.