Return to Main Site 617-919-3019
401 Park Drive, 7th Floor East, Boston, MA 02215

TIDO Technology Search



Invention Type

Diagnostic/Prognostic
Information Technology/Software
Medical Device
Other
Research Tool
Therapeutics

Research Area

Allergy/Respiratory/Pulmonary Disease
Anesthesia
Audiology
Cardiovascular/Cardiology
Degenerative Disease
Dermatology
Endocrinology
Gastrointestinal/Nutrition
Genetic Disease
Health Care Management
Immunology
Infectious Disease
Inflammation
Internal Medicine
Metabolic Disease
Musculoskeletal
Neonatology/Pediatric
Neurology/Neuroscience
Oncology/Hematology
Ophthalmology
Orthopedics
Otolaryngology/Audiology
Pain
Pathology
Personalized Medicine
Psychiatric Disease
Radiology
Regenerative Medicine
Reproduction/Ob-Gyn
Stem Cell
Surgery/Wound Healing
Urology
CMCC 2233

Device for endovascular maintenance and repairing the ascending aortic valve

Inventors: James Lock, Benjamin Kozyak

Invention Types: Medical Device

Research Areas: Cardiovascular/Cardiology

Keywords: Heart Disease, Medical Device, Minimally Invasive Surgery, Surgery

For More Information Contact:  Miracco, Amy

 

Invention Description:

Dr. Lock and Dr. Kozyak have developed devices for endovascular maintenance and repair of the aorta in instances of aortic dilation or aneurysm, as is commonly seen in patients with a variety of congenital heart defects such as bicuspid aortic valve, Marfan Syndrome, and others. Currently available therapies (endovascular or otherwise) for pathologic dilation of the proximal aorta are extremely invasive and present significant short and long-term risks to the patient.


Dr. Lock’s team has developed devices and methods of implantation that endeavor to reduce the invasiveness of therapeutic intervention surgery while reducing the need for multiple procedures and allowing for improved quality of life. The devices are innovative implantable grafts that can be deployed to treat dilated blood vessels, and prevent worsening enlargement. This is accomplished in several ways. By allowing a separation of the internal device lumen from the native vessel, the devices are able to modulate the effects of hydrostatic pressure on the vessel wall, limiting one of the primary drivers of progressive dilation. Devices may also comprise strategically oriented fasteners that engage the tissue of the vessel wall, stabilizing the device while mechanically constraining the vessel from further enlargement and enhancing its structural resilience.


While the devices are intended primarily for insertion into the ascending aorta, they can be applied throughout the body in any instance requiring mitigation of vascular dilation, or restriction of flow. Devices may also be fitted with, or coupled to, prosthetic valves, for use in patients with both vessel dilation and valvar dysfunction, as is commonly seen in patients with bicuspid aortic valve or other valve abnormalities.

Applications:

This device is a endovascular prosthesis designed for implantation by surgical or transcatheter techniques into the ascending aorta, or elsewhere in blood vessels that require structural support, management of vascular dilation, or restriction of flow.

Competitive Advantages:

• Reduces the invasiveness of surgical therapy for pathology of the proximal aorta.

• Introduces a novel method for preventing or reducing long-term pathologic dilation of the aorta, mitigating the need for vessel surgery and the associated risks.

• Reduces potential for continued vessel dilation and migration of artificial graft

Business Opportunity:

Exclusive or non-exclusive license

Key Publications: Not published

IPStatus: Pat. Pend.