Antibody against the N-terminus of GLT-1/EAAT2
Inventors: Paul Rosenberg
Invention Types: Research Tool
Research Areas: Neurology/Neuroscience
Keywords: AntibodyFor More Information Contact: Caron, Connie
Dr. Rosenberg has created a polyclonal antibody against the N terminus of GLT-1 (anti-nGLT-1), which detects both variant forms of GLT-1, GLT-1a and GLT-1b, generated in New Zealand White rabbits (Research Genetics) and characterized previously (Chen et al., 2002, 2004). This antibody was generated based on the published sequences for rat GLT-1a and GLT-1b (amino acids 1–15; GenBank accession number AF451299). This antibody has been shown to be useful in detecting EAAT2 (the human homolog of GLT-1) in tissue from human brain.
Antibody for Western blot analysis and immunocytochemistry
Nonexclusive license for research and/or commercial purposes
Key Publications: DeSilva TM, et al. Regulation of glutamate transport in developing rat oligodendrocytes. J Neurosci. 2009 Jun 17;29(24):7898-908.
DeSilva TM, et al. Expression of EAAT2 in neurons and protoplasmic astrocytes during human cortical development. J Comp Neurol. 2012 Dec 1;520(17):3912-32.
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