Return to Main Site 617-919-3019
401 Park Drive, 7th Floor East, Boston, MA 02215

TIDO Technology Search



Invention Type

Diagnostic/Prognostic
Information Technology/Software
Medical Device
Other
Research Tool
Therapeutics

Research Area

Allergy/Respiratory/Pulmonary Disease
Anesthesia
Cardiovascular/Cardiology
Degenerative Disease
Dermatology
Endocrinology
Gastrointestinal/Nutrition
Genetic Disease
Health Care Management
Immunology
Infectious Disease
Inflammation
Internal Medicine
Metabolic Disease
Musculoskeletal
Neonatology/Pediatric
Neurology/Neuroscience
Oncology/Hematology
Ophthalmology
Otolaryngology/Audiology
Pain
Pathology
Personalized Medicine
Psychiatric Disease
Radiology
Regenerative Medicine
Reproduction/Ob-Gyn
Stem Cell
Surgery/Wound Healing
Urology
CMCC 1826

Antibody against the N-terminus of GLT-1/EAAT2

Inventors: Paul Rosenberg

Invention Types: Research Tool

Research Areas: Neurology/Neuroscience

Keywords: Antibody

For More Information Contact:  Caron, Connie

 

Invention Description:

Dr. Rosenberg has created a polyclonal antibody against the N terminus of GLT-1 (anti-nGLT-1), which detects both variant forms of GLT-1, GLT-1a and GLT-1b, generated in New Zealand White rabbits (Research Genetics) and characterized previously (Chen et al., 2002, 2004). This antibody was generated based on the published sequences for rat GLT-1a and GLT-1b (amino acids 1–15; GenBank accession number AF451299). This antibody has been shown to be useful in detecting EAAT2 (the human homolog of GLT-1) in tissue from human brain.

Applications:

Antibody for Western blot analysis and immunocytochemistry

Business Opportunity:

Nonexclusive license for research and/or commercial purposes

Key Publications: DeSilva TM, et al. Regulation of glutamate transport in developing rat oligodendrocytes. J Neurosci. 2009 Jun 17;29(24):7898-908.

DeSilva TM, et al. Expression of EAAT2 in neurons and protoplasmic astrocytes during human cortical development. J Comp Neurol. 2012 Dec 1;520(17):3912-32.

IPStatus: No Protection