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CMCC 1720

Modulators of Nitric Oxide Signaling for the Stimulation Hematopoietic Stem Cells

Inventors: Leonard Zon, Trista North, Wolfram Goessling

Invention Types: Therapeutics

Research Areas: Oncology/Hematology

Keywords: Stem/Progenitor Cell

For More Information Contact:  Meyer, Abbie

 

Invention Description:

Dr. Zon's Lab has discovered that nitric oxide (NO) signaling is a conserved regulator of hematopoietic stem cell (HSC) development. During embryogenesis in both zebafish and mammals, the initial generation of blood flow is required in order to induce a NO-mediated stimulation of HSC proliferation and differentiation. Screening for chemical modulators of HSC proliferation, the Zon lab has discovered that compounds that stimulate NO generation or NO pathway response can enhance the proliferation of HSCs. This work provides a platform for the identification and testing of compounds for the stimulation of HSC proliferation and engraftment. Initial chemical hits provide leads for the development of novel therapeutics and new uses for existing pharmaceutics for HCS transplants.

Applications:

• Ex vivo treatment of bone marrow, peripheral blood stem cells or cord blood stem cells to enhancement of transplant engraftment

• In vivo stimulation of endogenous stem cells to promote hematopoietic system recovery

Competitive Advantages:

Enhanced of proliferation may aid the successful engraftment of hematopoietic stem cell transplant or stimulate endogenous HSCs to promote hematopoiesis.

Business Opportunity:

• Exclusive or non-exclusive license to a company

• Collaborative Research

Key Publications: North TE, Goessling W, Peeters M, et al. Hematopoietic stem cell development is dependent on blood flow. Cell. 2009 May 15;137(4):736-48.

Kong Y, Grimaldi M, Curtin E, et al. Neural crest development and craniofacial morphogenesis is coordinated by nitric oxide and histone acetylation. Chem Biol. 2014 Apr 24;21(4):488-501.

IPStatus: Pat. Pend.