Inventors: John Kheir, Mark Borden, Francis McGowan
Invention Types: Therapeutics
Research Areas: Cardiovascular/Cardiology, Neonatology/Pediatric
Keywords: Patient Care, PolymerFor More Information Contact: Chou, Jennifer
Dr. John Kheir and colleagues have developed a platform technology that packages oxygen in microbubbles for direct delivery via injection to blood and tissues. This technology is platform in nature and could revolutionize the practice of critical care medicine. An early and promising application is in treatment of patients who have undergone a myocardial infarction and experience cardiac arrest. The ability to keep blood oxygenated for even a short period of time under cardiac arrest circumstances or other circumstances in which a patient is unable to breathe or has no blood flow can prevent the tissue damage, including brain damage, that results from lack of oxygen.
Critial care; hypoxia of any cause:
Lung injury, lung disease
Traumatic brain injury
There is currently no way to oxygenate blood via injection. Particularly for cardiac arrest, current methods all depend on circulating blood. This technology has the potential to deliver oxygen to the deoxygenated heart tissue quickly and directly, providing it with essential metabolic energy.
Platform technology could be the basis for a start-up company. This technology could potentially be deployed in every ambulance, every operating room and every emergency room, and represents a large market opportunity.
Key Publications: Swanson EJ, et al. Phospholipid-stabilized microbubble foam for injectable oxygen delivery. Langmuir. 2010 Oct 19;26(20):15726-9.
Kheir JN, et al. Oxygen gas-filled microparticles provide intravenous oxygen delivery. Sci Transl Med. 2010 Jun 27;4(140):140ra88.
Kheir JN, et al. Bulk manufacture of concentrated oxygen gas-filled microparticles for intravenous oxygen delivery. Adv Healthc Mater. 2013 Aug;2(8):1131-41.
Seekell RP, et al. Oxygen delivery using engineered microparticles. Proc Natl Acad Sci USA. 2016 Nov 1;113(44):12380-5.
Seekell RP, et al. Tunable polymer microcapsules for controlled release of therapeutic gases. Langmuir. 2018 Aug 7;34(31):9175-83.
Related Publications: https://vector.childrenshospital.org/2016/11/intravenous-oxygen-delivery-edges-toward-the-clinic/