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CMCC 1419

Periostin as Injectable Therapeutic for Heart Failure

Inventors: Bernhard Kuhn

Invention Types: Therapeutics

Research Areas: Cardiovascular/Cardiology, Regenerative Medicine

Keywords: Large Molecule, Peptide, Protein

For More Information Contact:  Miracco, Amy

 

Invention Description:

The invention describes the use of periostin to stimulate differentiated cardiomyocyte proliferation. In vitro delivery of periostin induced adult cardiomyocytes to undergo cell cycle and proliferate, an effect that was specific for cardiomyocytes and not inducible by other cell cycle stimulating factors.


Effects of periostin were also demonstrated in vivo in myocardial infracted rats. Rats treated with a periostin-impregnated Gelfoam patch exhibited improved ventricular remodeling and cardiac function; detailed analysis of periostin-treated rat hearts showed increased ventricular wall thickness, thinner septum, less cellular hypertrophy, and after 12 weeks, a smaller scar volume. Although apoptosis of myocardial cells was evident in periostin-treated rats, an increased number of adult cardiomyocytes undergoing cell cycle was also exhibited in these rats, a result consistent with in vitro data and indicative that cardiomyocyte proliferation accounted for the improved cardiac function.

Applications:

Treatment of cardiomyocytes with periostin could be used to improve patient outcome after heart attack and rebuild heart tissue. Periostin therapy may limit the amount of damage to the heart after myocardial infarction and enhance cardiomyocyte proliferation resulting in rebuilding heart tissue and improving cardiac function.

Competitive Advantages:

Periostin has a direct affect on cardiomyocytes and not other cell types such as fibroblasts. Periostin can be delivered in a controlled manner to stimulate cardiomyocyte proliferation and cardiac repair over a prolonged time period.

Business Opportunity:

License, Start-up company, Sponsored Research

Key Publications: Nat. Med. 2007 8:962-9; PLoS ONE 2012 7(5): e36788

Related Publications: PCT: WO 2008/091867

IPStatus: Pat. Pend.