Endostatin Peptides with Anti-Tumor Properties
Inventors: M. Folkman, Kashi Javaherian, Robert Tjin Tham Sjin
Invention Types: Therapeutics
Research Areas: Oncology/Hematology
Keywords: Anti-angiogenesis, Composition of Matter, Peptide, Gene Therapy
Related Cases: 474, 1318For More Information Contact: Dietz, Ryan
Endostatin is a cleavage fragment from the C-terminal domain of collagen XVIII (see CMCC technology # 474) that has been developed as a clinical therapeutic, reaching phase II clinical trials with a very favorable safety profile. Endostatin and has been found to possess anti-angiogenic properties, including inhibition of endothelial cell proliferation, migration, and tube formation, as well as VEGF induced vascular permeability.
|Investigators at Children's Hospital Boston have identified a novel 27 amino acid fragment at the N terminus of endostatin that has anti-tumor, anto-angiogenic and anti-endothelial cell proliferation activity comparable to that of the full length protein. The peptide could be used as a therapeutic or the nucleic acid sequence that encodes it could be used as a gene therapy agent. The peptides have also been demonstrated to have activity against endometriosis (see CMCC technology # 1318).
The short synthetic endostatin peptides described here would be easier and cheaper to manufacture than the original form of endostatin, while anticipated to have a similar favorable safety and efficacy profile. The peptides represent new composition of matter with patents allowed as of early 2009 in the US and Europe.
Key Publications: A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity.
||Tjin Tham Sjin RM, Satchi-Fainaro R, Birsner AE, Ramanujam VM, Folkman J, Javaherian K.
||Cancer Res. 2005 May 1;65(9):3656-63.
||US Patent application 11/364,855 (allowed) and EPO patent application 04782583.1 (allowed)
Related Publications: Short synthetic endostatin peptides inhibit endothelial migration in vitro and endometriosis in a mouse model.
|Becker CM, Sampson DA, Short SM, Javaherian K, Folkman J, D'Amato RJ.
||Fertil Steril. 2006 Jan;85(1):71-7.