Ubiquitin Proteasome Inhibitors to Prevent Axon Degeneration
Inventors: Zhigang He, Zhai Qiwei, Jing Wang, Liqun Luo, Ryan Watts, Eric Hoopfer
Invention Types: Therapeutics
Research Areas: Neurology/Neuroscience
Keywords: Disease Model, Drug Screening, Small Molecule/DrugFor More Information Contact: Caron, Connie
Invention demonstrates that specific compounds that either inhibit the ubiquitin proteasome pathway or stabilize microtubules can delay axon degeneration and promote neuronal regeneration. It includes (i) Methods and compounds for delaying axonal degeneration in pathological conditions; (ii) Specific and multiple compounds that can be used as therapeutics for degenerative neuropathies or neuronal diseases of the central nervous system, as demonstrated in multiple rodent models for disorders such as ischemia, Huntington's disease or ALS; (iii) Same compounds as in (ii) could be used for therapeutics to promote neuronal regeneration, as indicated in traumatized rats.
Previous strategies designed to prevent neuronal cell death have resulted in limited success as therapies for neurodegeneration. It is likely that axon degeneration provides an early target for neurodegenerative disorders, as the methods and compounds provided in this technology suggest a delay in axon degeneration and disease progression.
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Key Publications: Zhai et al. Neuron, Vol. 39, 217-225, July 17, 2003.